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“Although the overall frequency of liver enzyme elevations across the over 1,400 participant safety databases of danuglipron was in-line with approved agents in the class,” the spokesperson explained, “this single asymptomatic participant in one of the dose-optimization studies” was sufficient to scrap development of the GLP-1 agonist

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(b) glycosylation of extracellular asparagine (Asn) residues, required for correct receptor folding, surface expression, and ligand binding (109)